Allergen immunotherapy and biologics combo effective in managing and preventing allergic asthma: Study

This study initially examined how traditional pharmacotherapy is used to treat asthma and noted the shortcomings of this approach in treating more severe cases of the condition. They then discussed how biological treatments may be used to control the latter and what requirements they have yet to address. The advantages of allergen immunotherapy, either alone or in conjunction with traditional pharmacotherapy and/or biological therapy in the treatment of allergic asthma from both a preventative and therapeutic standpoint were finally reviewed, adhering to the approach outlined in Data S1.

The study found that the sole disease-modifying method for treating allergies is AIT. Numerous studies demonstrate its advantages in treating and controlling asthma, including RDBPC clinical trials. In the individuals with allergic rhinitis, it can stop the condition from developing into allergic asthma. When allergic asthma has been diagnosed, AIT can either help the patient or at least stop the problem from getting worse. As a result of its conjunction with biological therapy, there is a growing chance that more patients may benefit from its effects. Overall, allergen immunotherapy treats illness by targeting IgE-mediated allergies that provides benefits which extend beyond symptomatic relief.

Reference:

Batard, T., Taillé, C., Guilleminault, L., Bozek, A., Floch, V. B., Pfaar, O., Canonica, W. G., Akdis, C., Shamji, M. H., & Mascarell, L. (2024). Allergen Immunotherapy for the Prevention and Treatment of Asthma. In Clinical & Experimental Allergy. Wiley. https://doi.org/10.1111/cea.14575