Awake Prone Positioning Improves Survival and Reduces Intubation in COVID-19 Patients: JAMA
Covid-19 Now Endemic in India
Researchers have found in a new study that awake prone positioning (APP) improves substantially survival without intubation and decreases mortality in patients with COVID-19 and acute hypoxemic respiratory failure (AHRF). APP, a non-invasive strategy in which patients are placed face down while awake, has been extensively applied during the pandemic, but its capacity to enhance clinical outcomes was uncertain. The study was conducted by Jian L. and colleagues published in the journal of JAMA Internal Medicine.
The meta-analysis included evidence up to August 1, 2024, from PubMed, Embase, the Cochrane Library, and ClinicalTrials.gov. The analysis included data from 3019 adult patients with COVID-19 and AHRF, 1542 of whom were in the APP group (mean age 59.3 years, 68.0% male) and 1477 in the control group (mean age 59.9 years, 66.3% male). The main outcome was survival without intubation, and secondary outcomes were intubation rate, hospital mortality, admission to the ICU, and invasive mechanical ventilation duration. For binary outcomes, logistic regression was employed, and for continuous outcomes, linear regression was employed.
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