Biologics associated with improved long-term lung function and asthma control, finds research
A new study published in the journal of Respiratory Investigation showed that in actual clinical practice, starting a biologics (BIOs) was linked to notable improvements in long-term lung function and asthma control in individuals with severe uncontrolled asthma.
Treatment for severe asthma, which is defined by impaired lung function, involves the use of high-dose inhaled corticosteroids (ICS) in conjunction with other controls. Severe asthma patients are more likely to experience asthma flare-ups, which hasten the deterioration of their lung function. Biologics (BIOs) have been shown to be beneficial in treating severe asthma in phase III studies and reports of actual clinical practice.
International clinical guidelines for severe asthma now include a number of BIOs that have been licensed in Japan. However, comparisons to before and after the start of BIOs were limited since the phase III trials had stringent inclusion/exclusion criteria and the real-world evidence was restricted to observations lasting up to a year with a single arm. Thus, this trial examined the long-term, 24-month efficacy of starting a BIO in individuals who were considered candidates for BIO treatment and had severe, uncontrolled asthma.
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