Brensocatib improves clinical outcomes in bronchiectasis patients: NEJM
Written By : Medha Baranwal
Medically Reviewed By : Dr. Kamal Kant Kohli
Published On 2020-11-27 04:25 GMT | Update On 2020-11-27 04:25 GMT
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Delhi: The use of brensocatib was shown to improve clinical outcomes in bronchiectasis patients, in a 24-week trial. The findings of the study are published in the New England Journal of Medicine. Brensocatib, an oral reversible inhibitor of dipeptidyl peptidase 1 (DPP-1), helped in reducing neutrophil serine protease activity.
Bronchiectasis patients experience frequent exacerbation that are thought to be linked to neutrophilic inflammation. In bronchiectasis patients, the quantity and activity of neutrophil serine proteases, including neutrophil elastase, are increased in the sputum, and are increased further during exacerbation.
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