Bronchial thermoplasty found safe, effective and durable treatment for severe asthma
USA: Five years after treatment with bronchial thermoplasty patients with severe asthma experienced a decrease in exacerbations, ED visits, hospitalization, and corticosteroid exposure, researchers report in a new study.
Bronchial thermoplasty is a device-based treatment used for people ≥ 18 years of age with severe asthma poorly controlled with inhaled corticosteroids and long-acting beta-agonists. In the Post-FDA Approval Clinical Trial Evaluating Bronchial Thermoplasty in Severe Persistent Asthma (PAS2) study, data collection in patients with severe asthma undergoing this procedure was done.
In the study published in the Chest Journal, Geoffrey Chupp, Yale University, New Haven, CT, and colleagues address the question of the 5-year efficacy and safety results in patients with severe asthma who have undergone bronchial thermoplasty.
The study was a prospective, open-label, observational, multicenter study conducted in the United States and Canada. People included were of 18 to 65 years of age who were taking inhaled corticosteroids ≥ 1,000 μg/d (beclomethasone or equivalent) and long-acting beta-agonists ≥ 80 μg/d (salmeterol or equivalent). The researchers evaluated hospitalization, severe exacerbations, medication usage, and ED visits for the 12 months prior to and at years 1 through 5 posttreatment. Also, spirometry was evaluated at baseline and at years 1 through 5 posttreatment.
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