Colistin nebulization improves clinical outcomes in ICU-admitted patients with nosocomial pneumonia
Taiwan: A study published in the Annals of Intensive Care has concluded that the patients treated with substitutive nebulized colistin have a lower rate of clinical failure and a similar mortality rate. The researchers reported comparable treatment outcomes and risk of nephrotoxicity based on patients treated with high- and low-dose nebulized colistin.
The researchers included critically ill patients with hospital-acquired pneumonia/ventilator-associated pneumonia (HAP/VAP caused by carbapenem-resistant Gram-negative bacteria (CR-GNB).
It is already known that nephrotoxicity is the most common adverse reaction of most significant concern reported with intravenous colistin treatment. There needs to be more data on the descriptive and relevant role of substitutive nebulized colistin for managing patients with nosocomial pneumonia caused by CR-GNB in critically ill patients.
Considering this, team of researchers led by Jia-Yih Feng investigated the effectiveness of substitutive nebulized colistin clinically in treatment outcomes of nosocomial pneumonia caused by CR-GNB. The researchers also explored the impact of the dosing strategy of nebulized colistin.
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