COVID-19 Severity decreased among patients with asthma, eosinophilia and noneosinophilic asthma
Recent study published in The Journal of Allergy and Clinical Immunology finds how COVID-19 affects individuals with respiratory conditions, specifically asthma and chronic obstructive pulmonary disease (COPD).
The retrospective cohort study, conducted on 8,395 COVID-19 patients admitted between March 2020 and April 2021, identified patients with asthma, COPD, and those without airway diseases using International Classification of Diseases, 10th Revision codes. The study focused on comparing mortality rates and Sequential Organ Failure Assessment (SOFA) scores among these groups and used logistic regression analysis to adjust for confounding clinical factors associated with mortality.
Patients without airway diseases had a median SOFA score of 0.32, with an 11% mortality rate. In contrast, asthma patients exhibited significantly lower SOFA scores (median 0.15) and a reduced mortality rate, even after accounting for age, diabetes, and other confounders. Patients with asthma showed a 35% lower risk of mortality.
However, for patients with COPD, the picture was quite different. They had higher SOFA scores (median 0.86) and a 40% increased adjusted risk of mortality. This suggests that individuals with COPD may be more susceptible to severe outcomes when infected with COVID-19.
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