CPAP reduces BP and cortisol levels in patients with sleep apnea: Study

Against the above background, Thang S. Han, University of London, Surrey, UK, and colleagues aimed to document changes in the levels of cortisol and blood pressure in response to CPAP treatment of OSA.

For this purpose, the researchers conducted a meta-analysis using RevMan (v5.3) and expressed in standardized mean difference (SMD) for catecholamines and mean difference for systolic (SBP) and diastolic blood pressure (DBP). The quality of the studies was evaluated using standard tools for assessing the risk of bias.

A total of 22 studies consisting of 16 prospective cohort studies (that recruited 385 participants) and six randomized control trials (totaling 252 participants) met the search criteria. The range of mean age was 41–62 years and BMI 27.2–35.1 kg/m2. 

Our findings show that CPAP treatment in individuals with OSA reduces cortisol levels and blood pressure, concluded the authors. 

Reference:

The study titled, "Changes in cortisol levels by continuous positive airway pressure in patients with obstructive sleep apnoea: Meta-analysis of 637 individuals," is published in the journal Clinical Endocrinology.

DOI: https://onlinelibrary.wiley.com/doi/full/10.1111/cen.14573