Endobronchial OCT safe and accurate method for microscopic ILD diagnosis: Study
Endobronchial Optical Coherence Tomography is a highly safe and effective technique for microscopic diagnosis of interstitial lung disease (ILD), suggests a study published in the American Journal of Respiratory and Critical Care Medicine.
Early, accurate diagnosis of interstitial lung disease (ILD) informs prognosis and therapy, especially in idiopathic pulmonary fibrosis (IPF). Current diagnostic methods are imperfect. HRCT resolution is limited while surgical lung biopsy (SLB) carries risks of morbidity/mortality. Endobronchial optical coherence tomography (EB-OCT) is a low-risk, bronchoscope-compatible modality that images large lung volumes in vivo with microscopic resolution, including subpleural lung, and has the potential to improve the diagnostic accuracy of bronchoscopy for ILD diagnosis. Objectives:
A group of researchers U.S.A performed a prospective diagnostic accuracy study of EB-OCT in ILD patients with a low-confidence diagnosis undergoing SLB.
Primary endpoints were EB-OCT sensitivity/specificity for the diagnosis of the histopathologic pattern of usual interstitial pneumonia (UIP) and clinical IPF. The secondary endpoint was an agreement between EB-OCT and SLB for diagnosis of the ILD fibrosis pattern. Methods: EB-OCT was performed immediately prior to SLB.
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