Eosinophil to platelet ratio can predict acute exacerbation of COPD

The results from the study highlighted the effectiveness of the EPR in patients of two groups with significantly different mortality rates (25.3% vs. 5.5%, P < 0.001) when the optimal area under the curve (AUC) cutoff of 0.755 was applied. The patients presenting in the emergency room with a lower EPR also expressed a higher mortality risk (35.6% vs. 11.1%, P < 0.001).

The research went a step further to develop a predictive model for death risk that included variables such as EPR < 0.755, exacerbation history, PaO2 < 60mmHg, PaCO2 > 50 mm Hg, hypoalbuminemia and age over 80 years. This comprehensive model demonstrated better performance in forecasting adverse outcomes for patients during severe COPD exacerbation.

These findings hold promise in transforming the assessment and management of COPD patients, particularly in emergency scenarios. The ability to predict outcomes based on the EPR offers clinicians a valuable tool to tailor interventions and improve patient care. This research outcomes contribute to a better understanding of AECOPD and further can opens avenues for more targeted and personalized approaches in emergency settings.

Source:

Hu, D., Huang, J., Zhao, W., Xu, M., Ma, Y., Gong, Z., Zhang, Q., & Zhao, H. (2024). A low eosinophil to platelet ratio as a worse prognostic index for emergency department attendance in acute exacerbation of COPD. International Journal of Chronic Obstructive Pulmonary Disease, 19, 139–147. https://doi.org/10.2147/copd.s442715