Ferritin-to-Albumin Ratio Predicts Mortality Risk in Non-COVID-19 Pneumonia Patients: Study
A new study has found that the ferritin-to-albumin ratio (FAR), a biomarker that reflects both inflammation and nutritional status, can predict short-term mortality in critically ill patients with non-COVID-19 pneumonia. The findings highlight how routinely available blood tests may offer valuable insights into patient outcomes, providing a practical way to identify those at higher risk.
The research, published in Respiratory Medicine (Feng et al., 2025), analyzed data from 827 patients admitted with pneumonia to the intensive care unit. By examining ferritin, a marker of systemic inflammation, alongside albumin, which reflects nutritional and physiological reserve, the team calculated each patient’s FAR and tracked survival over 28 and 90 days. Patients with higher ratios at admission consistently showed a greater risk of death during both time frames. This association remained significant even after adjusting for demographics, comorbidities, and other clinical variables. The results suggest that FAR captures the combined impact of inflammation and nutritional depletion on patient outcomes, offering a more holistic measure than single biomarkers alone.
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