In acute pulmonary embolism patients, reduced-dose alteplase as effective as full-dose alteplase: Study

Systemic thrombolysis improves outcomes in patients with pulmonary embolism (PE) but is associated with the risk of haemorrhage. The data on the efficacy and safety of reduced-dose alteplase are limited. The study objective was to compare the characteristics, outcomes, and complications of patients with PE treated with full- or reduced-dose alteplase regimens. Pre- and post-alteplase hemodynamic and respiratory variables, patient outcomes, and complications were compared. Propensity score (PS) weighting was used to adjust for imbalances of baseline characteristics between reduced- and full-dose patients. Separate analyses were performed using the unweighted and weighted cohorts. Ninety-eight patients were treated with full-dose (100 mg) and 186 with reduced-dose (50 mg) regimens. Following alteplase, significant improvements in shock index, blood pressure, heart rate, respiratory rate, and supplemental oxygen requirements were observed in both groups. Hemorrhagic complications were lower with the reduced dose compared with the full-dose regimen (13% vs. 24.5%, p = 0.014), and most were minor. Major extracranial haemorrhages occurred in 1.1% versus 6.1%, respectively (p = 0.022). Complications were associated with supratherapeutic levels of heparin anticoagulation in 37.5% of cases and invasive procedures in 31.3% of cases. The differences in complications persisted after PS weighting but did not reach statistical significance. There were no significant differences in mortality, discharge destination, ICU or hospital length of stay, or readmission after PS weighting.

In a retrospective, PS-weighted observational study, when compared with the full-dose, reduced-dose alteplase results in similar outcomes but fewer hemorrhagic complications. Avoidance of excessive levels of anticoagulation or invasive procedures should be considered to further reduce complications.

Reference:

Melamed, Roman MD1; Tierney, David M. MD2,3; Xia, Ranran PharmD4; Brown, Caitlin S. PharmD4,5; Mara, Kristin C. MS6; Lillyblad, Matthew PharmD7; Sidebottom, Abbey MPH, PhD8; Wiley, Brandon M. MD9; Khapov, Ivan MD10; Gajic, Ognjen MD, MSc11. Safety and Efficacy of Reduced-Dose Versus Full-Dose Alteplase for Acute Pulmonary Embolism: A Multicenter Observational Comparative Effectiveness Study. Critical Care Medicine ():10.1097/CCM.0000000000006162, January 02, 2024. | DOI: 10.1097/CCM.0000000000006162

Keywords:

acute PE patients, reduced-dose alteplase, full-dose alteplase, Melamed, Roman; Tierney, David M; Xia, Ranran Pharm; Brown, Caitlin S. Pharm; Mara, Kristin; Lillyblad, Matthew; Sidebottom, Abbey; Wiley, Brandon M; Khapov, Ivan; Gajic, Ognje