Genetically predicted sleep apnea Increases Risk of Diabetic Nephropathy, mediated by BMI and BP: Study
Researchers have found in a new study that genetically predicted obstructive sleep apnea (OSA) is linked to a higher risk of diabetic nephropathy. The study indicates that BMI and high blood pressure play important roles in the pathway through which OSA contributes to kidney damage in diabetes.
Previous observational studies have reported the association between obstructive sleep apnea (OSA) and diabetic nephropathy. However, it remains to be confirmed whether this association is causal. This study aimed to investigate the causal association of OSA with diabetic nephropathy and the mediating effect of common risk factors using Mendelian randomization (MR) design. The study data were sourced from genome-wide association studies (GWAS). Bidirectional two-sample MR and multivariable MR analyses were conducted to assess causal relationships between OSA and diabetic nephropathy. Potential mediation by common risk factors was evaluated through two-step MR. In addition, the MR results were supported by various sensitivity and validation analyses.
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