GERD Increases Risks for COPD and Asthma, Study Confirms
It has been found in a recent study published in Heliyon that individuals who are genetically predisposed to having gastroesophageal reflux disease (GERD) have a significantly increased risk of developing chronic obstructive pulmonary disease (COPD) and asthma. The study was conducted by Shan Lin and fellow researchers in China. This study used genome-wide association data from European cohorts to investigate the potential causal dynamics, offering crucial insights into preventive and therapeutic strategies.
A two-sample bidirectional Mendelian randomization approach was conducted to assess the causal effect of GERD on COPD and asthma risks. The results of this analysis used aggregated European genome-wide association study (GWAS) data. Robust statistical tests undertaken for the estimation of reliability involve the Cochran Q test and the funnel plot and MR-Egger intercept as well as the MR-PRESSO to validate heterogeneity along with pleiotropy. Confirmation of directional causality was tested through Steiger testing. Converse MR estimations were applied to check the hypothesis that the direction of causal effect could emanate from either COPD or from asthma on GERD.
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