High risk of asthma in children with orofacial defects, finds study
Taiwan: A recent study has shown that children with orofacial defects face a higher risk of developing asthma, with a possible contribution from oral microbiota in their early months. The study was published online in the journal Pediatric Pulmonology on July 20, 2023.
Patients with congenital orofacial defects, cleft palate (CP), cleft lip (CL), and cleft lip and palate (CLP) have continuous exposure of the respiratory system to the microbiome from the oral environment, offering opportunities for mucosal immunity development in the airway.
The study was conducted in two parts by Hsin-Chun Huang, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University, Kaohsiung, Taiwan, and colleagues, They aimed to analyze data on asthma occurrence in infants with cleft lip, cleft palate, and CLP and the composition of the salivary microbiome. Also, they evaluated the oral microbiota and its association with the risk of childhood asthma development.
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