Higher Mortality Patterns recorded with Central Sleep Apnea compared to Obstructive Sleep Apnea

The study results could be summarised as follows:

• The total number of patients in CSA and OSA were 2961 and 1,487,353, respectively.
• CSA patients were older than OSA-grouped patients.
• More death was reported in CSA-grouped patients, 25.1%, than those with OSA constituting 14.9 %.
• The adjusted HR was 1.53.
• Those with a history of HF, hemiplegia, and a BMI less than 18.5 were among the highest predictors of mortality in CSA.
• As per subgroup analysis, HF presence was associated with increased mortality in CSA with HR, 7.4, and OSA with HR, 4.3.

Concluding further, Clinically diagnosed Central Sleep Apnea was associated with a shorter time to death from the index diagnostic date. Within five years of diagnosis, nearly one-fifth of CSA patients died.

In this study, the researchers have high-pointed the highest predictors of mortality in CSA and found it to be more strongly associated with higher mortality than OSA, independent of associated comorbidity.

Further reading:

Mortality Patterns Associated with Central Sleep Apnea among Veterans: A Large, Retrospective, Longitudinal Report. https://doi.org/10.1513/AnnalsATS.202207-648OC