Higher Mortality Patterns recorded with Central Sleep Apnea compared to Obstructive Sleep Apnea
United States: A study published in the Annals of American Thoracic Society has concluded that the highest predictors of mortality in central sleep apnea (CSA) were Heart failure (HF) presence, cerebrovascular disease history and hemiplegia. The researchers found male sex predilection and being underweight were also among the mortality predictors in CSA. Compared to obstructive sleep apnea (OSA), CSA has higher mortality.
It is already known that CSA is strongly associated with high mortality. This research background is based on studies with limited sample sizes and homogeneous populations like HF.
Addressing this research gap further, researchers compared the mortality pattern and time to death between the CSA and OSA patients in the large Veterans Health Administration patient population. In the study, a big data analytic approach was used. A machine-learning algorithm determined the most critical predictor of time to death.
The study results could be summarised as follows:
- The total number of patients in CSA and OSA were 2961 and 1,487,353, respectively.
- CSA patients were older than OSA-grouped patients.
- More death was reported in CSA-grouped patients, 25.1%, than those with OSA constituting 14.9 %.
- The adjusted HR was 1.53.
- Those with a history of HF, hemiplegia, and a BMI less than 18.5 were among the highest predictors of mortality in CSA.
- As per subgroup analysis, HF presence was associated with increased mortality in CSA with HR, 7.4, and OSA with HR, 4.3.
Concluding further, Clinically diagnosed Central Sleep Apnea was associated with a shorter time to death from the index diagnostic date. Within five years of diagnosis, nearly one-fifth of CSA patients died.
In this study, the researchers have high-pointed the highest predictors of mortality in CSA and found it to be more strongly associated with higher mortality than OSA, independent of associated comorbidity.
Further reading:
Mortality Patterns Associated with Central Sleep Apnea among Veterans: A Large, Retrospective, Longitudinal Report. https://doi.org/10.1513/AnnalsATS.202207-648OC
Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.
NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.