Indocyanine Green effective and safe in localization of malignant pulmonary nodules
Indocyanine Green (ICG) is both effective and safe in the localization of malignant pulmonary nodules according to a recent study published in the Frontiers in Surgery.
Video-Assisted and Robotic-Assisted techniques become a constantly more prominent practice in thoracic surgery for lung cancer. Furthermore, the increased frequency in the detection of small lung cancers makes the intra-operative identification of these cancers even more challenging. Indocyanine Green (ICG) is one of the most commonly used dyes that assists surgeons to identify small lung cancers intra-operatively. The study aimed to evaluate the effectiveness and safety of ICG in lung cancer detection.
They performed a systematic review of the literature by screening the databases of MEDLINE, EMBASE, CENTRAL and Scopus until 30th April 2022 and the first 300 articles of Google Scholar for any suitable grey literature. We included any study that investigated the effectiveness of ICG in lung cancer detection. We excluded studies that explored the use of ICG only in the identification of intersegmental planes, lymph node mapping, case reports and non-English articles. We aimed to perform a meta-analysis on test accuracy studies using hierarchical summary receiver operating characteristic (HSROC) and the bivariate random-effects models. In cases where the data for a localization technique was not sufficient for that analysis, it was presented with tables with narrative purposes. Each study was assessed for Risk of Bias (RoB) and Applicability using the QUADAS-2 tool.
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