Inflammatory cells remain in blood after treatment of severe asthma, suggests research
Biological drugs have improved the lives of many people with severe asthma. However, a new study from Karolinska Institutet in Sweden shows that some immune cells with high inflammatory potential are not completely eradicated after treatment.
Biological drugs (biologics) have become an important tool in the treatment of severe asthma.
“They help most patients to keep their symptoms under control, but exactly how these drugs affect the immune system has so far remained unknown,” says Valentyna Yasinska, consultant in pulmonary medicine at Karolinska University Hospital and doctoral student at Karolinska Institutet’s Department of Medicine in Huddinge.
In a new study published in the scientific journal Allergy, researchers at Karolinska Institutet have explored what happens to the immune cells of patients being treated with biologics. By analysing blood samples from 40 patients before and during treatment, they found that instead of disappearing during treatment, certain types of immune cell – which play a key part in asthma inflammation – actually increased.
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