Insomnia Increases Respiratory Infections Risk by More Than 50%
Insomnia Increases Respiratory Infections Risk by More Than 50% suggests a new study published in the eBioMedicinePoor sleep is associated with an increased risk of infections and all-cause mortality but the causal direction between poor sleep and respiratory infections has remained unclear. The researchers examined if poor sleep contributes as a causal risk factor to...
Insomnia Increases Respiratory Infections Risk by More Than 50% suggests a new study published in the eBioMedicine
Poor sleep is associated with an increased risk of infections and all-cause mortality but the causal direction between poor sleep and respiratory infections has remained unclear. The researchers examined if poor sleep contributes as a causal risk factor to respiratory infections.
Researchers used data on insomnia, influenza and upper respiratory infections (URIs) from primary care and hospital records in the UK Biobank (N ≈ 231,000) and FinnGen (N ≈ 392,000). We computed logistic regression to assess association between poor sleep and infections, disease free survival hazard ratios, and performed Mendelian randomization analyses to assess causality.
Findings
Utilizing 23 years of registry data and follow-up, we discovered that insomnia diagnosis associated with increased risk for infections (FinnGen influenza Cox’s proportional hazard (CPH) HR = 4.34 [3.90, 4.83], P = 4.16 × 10−159, UK Biobank influenza CPH HR = 1.54 [1.37, 1.73], P = 2.49 × 10−13). Mendelian randomization indicated that insomnia causally predisposed to influenza (inverse-variance weighted (IVW) OR = 1.65, P = 5.86 × 10−7), URI (IVW OR = 1.94, P = 8.14 × 10−31), COVID-19 infection (IVW OR = 1.08, P = 0.037) and risk of hospitalization from COVID-19 (IVW OR = 1.47, P = 4.96 × 10−5).
The findings indicate that chronic poor sleep is a causal risk factor for contracting respiratory infections, and in addition contributes to the severity of respiratory infections. These findings highlight the role of sleep in maintaining sufficient immune response against pathogens.
Reference:
Samuel E. Jones i, Fahrisa I. Maisha i, Satu J. Strausz, Vilma Lammi, Brian E. Cade
Anniina Tervi, et al.The public health impact of poor sleep on severe COVID-19, influenza and upper respiratory infections. eBioMedicine. Open AccessPublished:June 08, 2023DOI:https://doi.org/10.1016/j.ebiom.2023.104630
Keywords:
Insomnia, Increases, Respiratory, Infections, Risk, More , Than 50%, eBioMedicine, Samuel E. Jones i, Fahrisa I. Maisha i, Satu J. Strausz, Vilma Lammi, Brian E. Cade, Anniina Tervi, Insomnia, COVID-19, Respiratory infections, Mendelian randomization, Sleep, Severe infection
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