Low Vitamin D Levels in Early Childhood Linked to Asthma among infants with bronchiolitis: Study
Researchers have found in a new study that Children with a history of severe bronchiolitis in infancy who had low serum 25-hydroxyvitamin D (< 20 ng/mL) at age 3 had a higher risk of developing eosinophilic asthma or eosinophilia without asthma by age 6.
Beyond its well-known function in calcium homeostasis and bone health, vitamin D plays an important role in immune modulation and, possibly, the etiology of allergic diseases.
Studies have shown an association between vitamin D deficiency and asthma incidence and control. Moreover, there is an association between early-life blood eosinophil levels and asthma incidence, consistent with a distinct eosinophilic asthma endotype.
Pediatric studies report an inconsistent association between serum 25-hydroxyvitamin D (25[OH]D) and eosinophilia. Additionally, no studies have investigated the association between serum 25(OH)D and eosinophilic asthma among children with a history of severe (requiring hospitalization) bronchiolitis. Bronchiolitis is the most common cause of infant hospitalization in the United States and a major risk factor for childhood asthma.
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