Metformin lowers asthma exacerbations independent of blood sugar control: Study
Usage of Metformin, irrespective of blood sugar level control and obesity was linked with a lower probability of asthma-associated Emergency Department visits and hospitalizations, suggests a study published in The Journal of Allergy and Clinical Immunology: In Practice.
Worse asthma morbidity is closely related to diabetes. Metformin, commonly given in diabetic patients, may have a role in patients with asthma and glycaemic dysfunction or poor blood sugar control.
A group of researchers from Johns Hopkins University School of Medicine, Baltimore Maryland, U.S.A conducted a study to demonstrate an association between metformin use and asthma exacerbations among patients with diabetes.
They selected a total of 1,749 adults with asthma and diabetes who were reported in the Johns Hopkins EHR from April 1, 2013 to May 31, 2018. All the adults with asthma and diabetes were followed from the first hemoglobin A1c (HbA1c) test to an asthma-related systemic corticosteroid prescription, emergency department (ED) visit, or hospitalization. Multivariable Cox models estimated time to each outcome associated with metformin use, modeled as either time-invariant (status at HbA1c testing) or time-dependent (based on fill data). Mediation of results by HbA1c was assessed. Also, sensitivity analysis was performed by propensity score matching.
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