New Soft "sweat stickers" may streamline diagnosis of cystic fibrosis in children
Cystic fibrosis is diagnosed in infants by use of sweat testing as elevated chloride concentrations in sweat are indicative of cystic fibrosis. The current approach can have poor sensitivity and require repeated testing. For further reference log on to: http://dx.doi.org/10.1126/scitranslmed.abd8109;
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A sweat sticker on an infant after the conclusion of a sweat test. This material relates to a paper that appeared in the Mar. 31, 2021, issue of Science Translational Medicine, published by AAAS. The paper, by T.R. Ray at University of Hawaii at Manoa in Honolulu, HI; and colleagues was titled, "Soft, skin-interfaced sweat stickers for cystic fibrosis diagnosis and management."
The concentration of chloride in sweat remains the most robust biomarker for confirmatory diagnosis of cystic fibrosis (CF), a common life-shortening genetic disorder. Early diagnosis via quantitative assessment of sweat chloride allows prompt initiation of care and is critically important to extend life expectancy and improve quality of life.
Cystic fibrosis is diagnosed in infants by use of sweat testing as elevated chloride concentrations in sweat are indicative of cystic fibrosis. The current approach can have poor sensitivity and require repeated testing.
New "sweat stickers" may streamline the early diagnosis of cystic fibrosis by enabling scientists to easily gather and analyze sweat from the skin of infants and children.
The stickers matched the performance of previous, more cumbersome devices when tested with 51 subjects, suggesting the stickers could address design obstacles that have held back the diagnosis and treatment of cystic fibrosis in pediatric patients.
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