Novel drug delivered through nasal spray promising treatment for sleep apnea

Australia: A novel, potent, TASK 1/3 channel antagonist, BAY2586116, in development for obstructive sleep apnoea (OSA), has yielded positive results in research published in CHEST Journal, which tested the drug in people for the first time. 

The study tested the drug on 12 people with OSA using either nasal drops, a nasal spray, or a direct application using an endoscope versus a placebo.

The treatment is designed to prevent the narrowing or collapse of the upper airways during sleep, a key factor in OSA; the treatment could prove to be a potential alternative for certain people with OSA to continuous positive airway pressure (CPAP) machines, which can only be tolerated by about half of all OSA sufferers.

"While further rigorous clinical evaluation and testing is required, this is a great first step and should offer some hope to the many people worldwide who suffer from sleep apnoea," says study senior author Professor Danny Eckeart, Director of Flinders University's sleep lab FHMRI: Sleep Health.

"OSA is one of the most common sleep-related breathing disorders, with an estimated one billion sufferers, and when untreated, it is associated with major health and safety consequences. While CPAP machines are effective, tolerance remains a major issue for many, and other treatments, such as dental splints and upper airway surgery, don't always work. This is why we need new treatment options for OSA.