Risk of Post-Acute Sequelae of SARS-CoV-2 Remains High Even with Vaccination During Omicron Era: Study
United States: A recent study published in the New England Journal of Medicine concluded that throughout the pandemic, the cumulative incidence of PASC during the first year after SARS-CoV-2 infection decreased whereas in the omicron era, the risk of post-acute sequelae of SARS-COV-2 infection remained substantial among vaccinated persons who had SARS-CoV-2 infection.
Post-acute sequelae of SARS-CoV-2 infection (PASC), commonly referred to as long COVID. It refers to a range of symptoms that persist for weeks or months after the acute phase of COVID-19 has resolved. Fatigue, tiredness, shortness of breath, cough, headache, joint pain etc are the common symptoms that are associated with SARS-CoV-2 infection. Considering this, Yan Xie, from the Division of Pharmacoepidemiology (Y.X.), Washington University, St.Louis, et.al conducted a study to evaluate the cumulative incidence of PASC during the first year after SARS-CoV-2 infection.
For this purpose, the research team used the records of the Department of Veterans Affairs from March 1, 2020, and January 31, 2022, to build a study population of 441,583 veterans who were infected with SARS-CoV-2 infection and 4,748,504 noninfected participants were used as a control group. After 1 year of SARS-CoV-2 infection, the cumulative incidence of PASC was estimated during the pre–delta, delta, and omicron eras of covid-19.
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