Do individuals with sarcoidosis have a greater long-term risk of developing VTE (pulmonary embolism or deep venous thrombosis) compared to the general population?
Danish nationwide registries were used. Patients >18 years with newly diagnosed sarcoidosis (>2 in/outpatient visits, 1996-2020) without prior VTE were matched 1:4 by age, sex, and comorbidities with individuals from the background population. Venous thromboembolism was the primary outcome.
Key findings from the study are:
· 14,742 patients with sarcoidosis and 58,968 matched individuals of median age 44.7 years were included.
· Of these patients, 57.2% were males.
· The median follow-up duration was 8.8 years.
· The absolute 10-year risks of VTE, pulmonary embolism, and deep venous thrombosis for patients with sarcoidosis were 2.9%, 1.5%, and 1.6%, respectively, compared to 1.6%, 0.7%, and 1.0% in the background population.
· Sarcoidosis was associated with an increased rate of all outcomes in the first year after diagnosis and after the first year compared with the background population.
· Excluding cancer patients and censoring those with incident cancer, the associations persisted.
· Three-month mortality was not significantly different between VTE patients with and without sarcoidosis (adjusted HR 0.84)
The occurrence of VTE during sarcoidosis is associated with a more severe disease and a poorer prognosis. The occurrence of VTE during sarcoidosis might signal a more inflammatory and/or evolutive disease in sarcoidosis/VTE patients and should be taken in consideration when designing therapeutic strategies for them.
In this nationwide cohort study, sarcoidosis was associated with an increased long-term risk of developing venous thromboembolism (VTE) compared to a matched background population.
Reference:
Yafasova A et al. Long-term risk of venous thromboembolism in sarcoidosis: a nationwide cohort study. Chest. 2024 Jan 29:S0012-3692(24)00134-X. doi: 10.1016/j.chest.2024.01.042.
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