Sarcoidosis tied to greater risk of developing venous thromboembolism: Study

Written By : Aditi

Medically Reviewed By : Dr. Kamal Kant Kohli

Published On 2024-03-01 16:30 GMT | Update On 2024-03-02 05:51 GMT

Chronic inflammation has been increasingly identified as a potential risk factor for VTE. While research on this topic is ongoing, it is essential to note that limited data is available on the risk of VTE in patients with sarcoidosis. This condition affects the immune system and causes granuloma formation.

According to a study published in Chest, sarcoidosis is associated with a higher long-term risk of VTE (pulmonary embolism or DVT, and each of these individually).

Using Danish nationwide registries, patients aged 18 or older with a recent diagnosis of sarcoidosis (having attended two or more inpatient/outpatient visits between 1996 and 2020) and without a prior history of VTE were matched based on age, gender, and comorbidities. The primary goal of this study was to determine the incidence of VTE.

Key findings from the study are:

• 14,742 patients with sarcoidosis and 58,968 matched individuals of median age, 44.7 years were included.

• The median follow-up duration was 8.8 years.

• Absolute 10-year risks of outcomes for patients with sarcoidosis vs the background population for VTE, pulmonary embolism and DVT was 2.9% vs 1.6%, 1.5% vs 0.7% and 1.6% vs 1.0%, respectively.

• In multivariable Cox regression, sarcoidosis increased the rate of all outcomes in the first year after diagnosis (VTE: hazard ratio [HR], 4.94;) and after the first year (VTE: HR, 1.65) compared with the background population.

• These associations persisted when excluding patients with a history of cancer and censoring patients with incident cancer during follow-up.

• Three-month mortality was not significantly different between patients with VTE with and without sarcoidosis, with adjusted HR of 0.84

In this nationwide cohort study, it was observed that individuals with sarcoidosis had a significantly higher risk of developing venous thromboembolism (VTE) in the long run compared to a control group matched for relevant factors.

Reference:

Yafasova, A., Fosbøl, E. L., Gustafsson, F., Krintel, S. B., Kristensen, S. L., Schou, M., Petersen, J. H., Sun, G., Rossing, K., Doi, S. N., Køber, L., & Butt, J. H. (2024). Long-term risk of venous thromboembolism in sarcoidosis: a nationwide cohort study. Chest. https://doi.org/10.1016/j.chest.2024.01.042

Article Source : Chest

Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.

NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.

Aditi

Dr. Aditi Yadav is a BDS, MDS in Periodontics and Implantology. She has a clinical experience of 5 years as a laser dental surgeon. She also has a Diploma in clinical research and pharmacovigilance and is a Certified data scientist. She is currently working as a content developer in e-health services. Dr. Yadav has a keen interest in Medical Journalism and is actively involved in Medical Research writing.

Comments Policy

Our comments section is governed by our Comments Policy . By posting comments at Medical Dialogues you automatically agree with our Comments Policy , Terms And Conditions and Privacy Policy .

Sarcoidosis tied to greater risk of developing venous thromboembolism: Study

Similar News

Rising Burden of Asthma and COPD Among Older Indians Linked to Social and Household Factors, Finds Study

Interferon alpha Nasal Spray Reduces COVID-19 Risk in Cancer Patients: Study

Azelastine Nasal Spray May Lower COVID-19 Infection Risk: JAMA

Metals and sulfate in air pollution mixture may contribute most to asthma hospitalizations: Study

Betel Quid Use Linked to Higher Risk of COPD Deaths, Study Finds

Over Half of Indian Patients With Nasal Symptoms Have Allergic Rhinitis: Study Finds

15 Percent of COPD Exacerbation Patients Develop Arrhythmias, Tripling In-Hospital Death Risk: Meta-Analysis

Mouth Breathing Linked to Sleep-Disordered Breathing in Children, finds study