Sleep apnea patients with morning chronotype may derive more CPAP benefits
USA: OSA (obstructive sleep apnea) patients with a morning chronotype have a clinically meaningful increase in CPAP (continuous positive airway pressure) adherence compared with other chronotypes, as shown by a secondary analysis of the randomized APPLES trial.
The findings, published in Annals of the American Thoracic Society, imply that chronotype may be a novel predictor of CPAP adherence, although mechanisms of this association need further study. The Morningness-Eveningness Questionnaire (MEQ) defines the chronotype, which measures when a person's circadian rhythm produces peak alertness.
Melissa P Knauert, Yale School of Medicine, Internal Medicine, New Haven, Connecticut, United States, and colleagues reported that patients with the morning chronotype (early birds) used their CPAP machines for 32 more minutes per night than their intermediate chronotype counterparts over six months of use.
Considering that poor adherence limits the effectiveness of CPAP therapy for obstructive sleep apnea, a better understanding of CPAP adherence would be required to develop novel strategies to improve it. Therefore Dr Knauert and the team aimed to determine if the chronotype (morning, evening or intermediate) of OSA patients is associated with differences in CPAP adherence. They also decided if such as association exists to determine the mechanism underlying this association.
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