Solriamfetol improves daytime sleepiness irrespective of sleep apnea treatment: Study

Key findings of the study include:

• At baseline, 324 (70.6%) participants were adherent (positive airway pressure use ≥4 hours/night on ≥70% nights, surgical intervention, or oral appliance use on ≥70% nights) and 135 (29.4%) nonadherent.
• Least squares (LS) mean differences (95% CI) from placebo in MWT sleep latency (minutes) in the 37.5-, 75-, 150-, and 300-mg groups among adherent participants were 4.8, 8.4, 10.2, 12.5 and among nonadherent participants were 3.7, 9.9, 11.9, 13.5.
• On ESS, LS mean differences from placebo in the 37.5-, 75-, 150-, and 300-mg groups among adherent participants were -2.4, -1.3, -4.2, -4.7 and among nonadherent participants were -0.7, -2.6, -5.0, -4.6 (-7.0, -2.3).
• Common adverse events: headache, nausea, anxiety, decreased appetite, nasopharyngitis, diarrhea.
• No clinically meaningful changes were seen in primary OSA therapy use with solriamfetol.