Tezepelumab Shows Promise in Treating Severe Asthma with or without Nasal Polyps
A recent study published in Journal Of Asthma And Allergy by LaidLaw T M and colleagues highlights the potential of tezepelumab, a human monoclonal antibody that blocks thymic stromal lymphopoietin, in the treatment of severe asthma, with or without nasal polyps (NPs). The phase 3 NAVIGATOR study (NCT03347279) revealed that tezepelumab reduced annualized asthma exacerbation rates (AAERs) compared to a placebo, regardless of baseline disease characteristics. Moreover, the treatment improved lung function, symptom control, and health-related quality of life (HRQoL) in adults and adolescents with severe, uncontrolled asthma.
Key findings from the study:
● Reduction in AAER: Tezepelumab led to an 85% reduction in AAER over 52 weeks versus placebo in patients with nasal polyps and a 51% reduction in patients without nasal polyps.
● Improved Lung Function: Tezepelumab demonstrated improvements in lung function, asthma control, and HRQoL at week 52 compared to placebo in both patient groups.
● Sino-Nasal Symptoms: In patients with nasal polyps, tezepelumab significantly reduced Sino-Nasal Outcome Test (SNOT)-22 total scores by 28 weeks (–12.57 points) and 52 weeks (–10.58 points) compared to placebo.
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