Thyroid Function Alterations Linked to Respiratory Allergies, study shows

• Allergen Sensitivities : Skin prick test showed that house dust mites are the most common cause of allergy with 55.2% sensitivity.

• Serum IgE Levels: Patients with respiratory allergies also had significantly higher serum IgE levels (mean = 36.85 IU/mL) among the patients with both allergic rhinitis and asthma (mean = 218 IU/mL).

• Thyroid Hormone Differences: There was a statistically significant difference between the groups concerning serum T4 levels in allergic rhinitis (p< 0.001 and p<0.05).

• Metabolic and Endocrine Correlations: The correlation analysis revealed correlations between age, BMI, and thyroid hormones and showed sex-specific differences (p<0.05 and p<0.01).

• BMI was within normal limits in all study groups, meaning that there is no direct metabolic abnormality with regard to thyroid function or respiratory allergies.

This study illustrates that alterations in thyroid function are significantly associated with respiratory allergies, especially in males. The endocrine, metabolic, and immune systems interactions may become potential targets for therapeutic interventions. Further research would be required to study the underlying mechanisms and develop personalized treatments for the individuals affected.

Reference:

Lokaj-Berisha, V., Gacaferri Lumezi, B. Increased thyroxine levels of patients with allergic rhinitis. Sci Rep 15, 2667 (2025). https://doi.org/10.1038/s41598-025-85762-0