Understanding Monoclonal Antibody in Treatment of Hospitalized Patients with COVID-19
Hospitalized COVID-19 patients reported having high mortality rates (10-30%). Casirivimab and imdevimab antibody cocktail (REGEN-COV®) are authorized in various countries for use in outpatients with COVID-19 and in post-exposure prophylaxis. The current trial was an adaptive, phase 1/2/3, double-blinded, placebo-controlled trial to evaluate the efficacy, safety, and tolerability of REGEN-COV in hospitalized adult patients with COVID-19 (on low-flow or no supplemental oxygen). The study was conducted at 103 sites in the United States, Brazil, Chile, Mexico, Moldova, and Romania.
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