Breast MRI identifies lesions in patients with normal mammogram, ultrasound: Study

France: Breast MRI can be useful for the management of patients with suspicious nipple discharge and normal ultrasound and mammogram, finds a recent study in the journal European Radiology. In such patients, MRI demonstrated excellent performance for the identification of lesions that required excision. Normal MRI indicates it is safe to propose follow-up only management, thus avoiding unnecessary duct excision.

Martine Boisserie-Lacroix, Department of Radiology, Institut Bergonié, Comprehensive Cancer Centre, Bordeaux, France, and colleagues aimed to evaluate the diagnostic accuracy of breast MRI in identifying lesions requiring excision for patients with  suspicious nipple discharge but normal mammograms and ultrasounds.

The prospective multicenter study consecutively included 106 female participants; 102 were retained for analysis. MRI was considered negative in the absence of suspicious enhancement and positive in cases of ipsilateral abnormal enhancement (BI-RADS 3 to 5).

Final diagnoses were based on histological findings of surgical or percutaneous biopsies or at 1-year follow-up. The researchers considered all lesions requiring excision found on pathology (papilloma, atypia, nipple adenomatosis, or cancer) as positive results. Spontaneous resolution of the discharge at 1 year was considered as a negative result. 

"In patients with suspicious nipple discharge and normal mammogram and ultrasound, MRI demonstrates excellent performance to identify lesions for which excision is required," wrote the authors. "Normal MRI indicates it is safe to propose follow-up only management, thus avoiding unnecessary duct excision."

Reference:

The study titled, "Diagnostic accuracy of breast MRI for patients with suspicious nipple discharge and negative mammography and ultrasound: a prospective study," is published in the journal European Radiology.

DOI: https://link.springer.com/article/10.1007/s00330-021-07790-4