CT may identify patients with high-risk nonalcoholic fatty liver disease
Leesburg, VA, - According to ARRS' American Journal of Roentgenology(AJR), Fibrosis-4 (FIB-4) and multiple CT findings can identify patients with high-risk nonalcoholic fatty liver disease (NAFLD)--advanced fibrosis or cirrhosis, that is--though the presence of nonalcoholic steatohepatitis (NASH) remains elusive on CT.
"Subjective assessment of multiple morphologic and separately quantified parameters by trained readers and a simple quantitative three-parameter model combining two CT features, liver surface nodularity (LSN) and liver segmental volume ratio (LSVR), and a clinical score (FIB-4) showed good association with presence of advanced fibrosis," wrote first author Meghan G. Lubner from the department of radiology at the University of Wisconsin School of Medicine and Public Health.
Based on a presentation at the ARRS 2019 Annual Meeting, Honolulu, HI, patients with biopsy-proven NAFLD who underwent CT within 1 year of biopsy were included. An experienced gastrointestinal pathologist performed a histopathologic review to determine steatosis, inflammation, and fibrosis. The presence of any lobular inflammation and hepatocyte ballooning was categorized as nonalcoholic steatohepatitis (NASH), while patients with NAFLD and advanced fibrosis (stage F3 or higher) were categorized as having high-risk NAFLD. Two readers subjectively assessed the presence of NASH and fibrosis.
https://www.ajronline.org/doi/10.2214/AJR.20.22842
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