Ferumoxytol-enhanced MRI good enough for detection of brain metastases: AJR
Portland, OR: Ferumoxytol-enhanced Magnetic resonance imaging is as effective as gadolinium-enhanced MRI for the detection of intracranial metastatic disease, suggests a recent study in the American Journal of Roentgenology. This could allow the use of ferumoxytol-enhanced Magnetic resonance imaging in improving workup and monitoring of brain metastases in case gadolinium-enhanced Magnetic resonance imaging is contraindicated.
Bronwyn E. Hamilton, Department of Radiology, Oregon Health & Science University, Portland, OR, and colleagues investigated whether ferumoxytol-enhanced MRI is as effective as standard-of-care gadolinium-enhanced MRI for the detection of intracranial metastatic disease.
The researchers retrospectively reviewed all patients who underwent imaging as part of two ongoing ferumoxytol-enhanced and gadolinium-enhanced MRI protocol studies to compare the number and size of enhancing metastatic lesions. Enhancing metastases on ferumoxytol-enhanced MR images and control on gadolinium-enhanced MR images were measured independently by two neuroradiologists. The size and number of metastases were compared on intraindividual basis. They recorded primary diagnoses. Differences in cubic root of volume between gadolinium-enhanced and ferumoxytol-enhanced MRI were compared using a linear mixed-effects model.
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