Gallium 68-labeled FAPI-PET promising for biliary tract cancer detection: Study
China: Gallium 68-labeled fibroblast-activation protein inhibitor (FAPI)-PET imaging is superior to current methods for more accurate staging of biliary tract cancer (BTC), thereby improving treatment decision making, states a recent study in Radiology.
In previous studies, Gallium 68–labeled fibroblast-activation protein inhibitor (68Ga-FAPI) is imaging for tumor detection that represents a promising alternative to fluorine 18 fluorodeoxyglucose (18F-FDG). Lianjun Lan, a radiologist at the Affiliated Hospital of Southwest Medical University in Luzhou, and colleagues, therefore, aimed to compare the potential efficacy of 68Ga-FAPI PET/CT with that of 18F-FDG PET/CT for detecting primary tumor and nodal and distant metastases in biliary tract cancer and to explore the impact (tumor staging) of 68Ga-FAPI compared with 18F-FDG on clinical management of BTC in a single-center prospective clinical study.
The study was performed at the Affiliated Hospital of Southwest Medical University between June 2020 and June 2021. Patients with BTC underwent both 68Ga-FAPI and 18F-FDG PET/CT. Histopathologic examination, morphologic imaging, and/or follow-up imaging served as the reference standard.
The paired-sample t-test was used to compare the maximum standardized uptake value (SUVmax) of the primary tumor and nodal and distant metastases between 18F-FDG and 68Ga-FAPI PET/CT.
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