Interval Breast Cancers more lethal than ones detected during routine Mammography: JAMA
Researchers have found that Invasive breast cancer is associated with a higher mortality rate than cancer detected during a routine screening mammogram. The new study has been published in JAMA Network Open.
Interval breast cancer is a term given to cancers detected/presenting within 12 months after a mammographic screening in which findings are considered normal. It is considered a strong indicator of how successful any screening program is.
Breast cancer comprises a highly heterogeneous group of diseases. Many breast cancers, particularly the more lethal ones, may not satisfy the assumptions about biology and natural history of breast cancer necessary for screening mammography to be effective.
Using Canadian health registries, researchers studied nearly 70,000 women aged 50–64 who had screening mammograms between 2004 and 2010. Roughly 700 invasive breast cancers were detected on screening, while 200 were detected in the 2-year interval after a normal screening mammogram. Higher-grade and estrogen-receptor-negative tumors were more common among interval than screen-detected tumors.
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