Intraoperative MRI successfully predicts newly diagnosed supratentorial glioblastoma: Study
These MRI scans show diffuse white matter abnormality (DWMA). The top three panels display raw MRI images from very preterm infants born at 27 weeks (left), 26 weeks (center) and 31 weeks (right) gestation. Higher signal intensity can be seen in the central white matter, particularly for the 31-week gestation infant. The bottom panels display the corresponding slices with objectively segmented DWMA in yellow. The 27-week infant (left) was diagnosed with mild DWMA, the 26-week infant (center) was diagnosed with moderate DWMA, and the 31-week infant had severe DWMA.
CREDIT
Cincinnati Children's and Nature Scientific Reports
USAGE RESTRICTIONS
According to researchers from the Department of Neurosurgery, Washington University School of Medicine, St. Louis, Missouri, Gross-total resection (GTR) increased the overall survival rate for patients with newly diagnosed glioblastoma after adjusting for other prognostic factors and that iMRI increased EOR and GTR rate which was considered as a significant predictor of GTR.
This study is published in the Journal of Neurosurgery.
High-grade gliomas (HGGs) continue to carry poor prognoses, and patient outcomes depend heavily on the extent of resection (EOR). The utility of conventional image-guided surgery is limited by intraoperative brain shift. More recent techniques to maximize EOR, including intraoperative imaging and the use of fluorescent dyes, combat these limitations. However, the relative efficacy of these two techniques has never been systematically compared. There is rising evidence that in glioblastoma (GBM) surgery an increase of extent of resection (EoR) leads to an increase in patient survival. Intraoperative MRI (iMRI) is used in the surgical treatment of glioblastoma, with uncertain effects on outcomes.
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