MRI-guided biopsy helps evaluate chemotherapy response in breast cancer: JAMA
According to the findings reported in a recent study, it has been noted that MRI-guided breast biopsy may be an effective way to evaluate complete response to neoadjuvant chemotherapy in women with breast cancer, as published in the JAMA Open Network.
Dr. Elizabeth Sutton and colleagues from the Memorial Sloan Kettering Cancer Center in New York City conducted the study to find an alternative, noninvasive methods to diagnose pathologic complete response in patients after neoadjuvant chemotherapy. They used MRI-guided biopsy to identify all but one patient with lingering invasive cancer after chemotherapy.
A total of 20 participants were enrolled in the study, all of whom underwent a standard-of-care neoadjuvant chemotherapy followed by definitive surgery to treat stage IA to IIIC invasive breast cancer. Non- contrast-enhanced MRI before and after the neoadjuvant chemotherapy regimen was administered to all of them.
The patients were scanned using a 1.5-tesla or 3-tesla whole-body MRI scanner equipped with a breast coil. Using MRI guidance and a vacuum-assisted biopsy system, the authors removed seven to 12 tissue samples from each patient and marked the biopsy incision site at the tumor location before the start of chemotherapy.
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