O-RADS MRI has high diagnostic performance for characterizing adnexal lesions: Study

For this purpose, the researchers performed a systematic literature search from 2013 to 2022. It included studies reporting pelvic MRI use with the O-RADS or ADNEX MRI systems to characterize ultrasound-indeterminate adnexal lesions, with pathologic examination and follow-up as the reference standard.

The authors investigated the effects of covariates on heterogeneity, and diagnostic performance was investigated. The bivariate random-effects model was used to obtain the summary estimates of diagnostic performance. In contrast, a random-effects model was used to get category-wise summary malignancy rates of O-RADS MRI 2, 3, 4, and 5 lesions.

The inclusion criteria were met by thirteen study parts from 12 studies comprising 3731 women with 4520 adnexal lesions.

Key findings of the study include:

· Diagnostic performance meta-analysis for 4012 lesions found a 91% summary specificity and 92% summary sensitivity.

· The meta-analysis of malignancy rates for 3641 lesions revealed summary malignancy rates of 0.1% among O-RADS MRI 2 lesions, 6% among O-RADS MRI 3 lesions, 60% among O-RADS MRI 4, and 96% among O-RADS MRI 5 lesions.

"Pelvic MRI interpreted with the O-RADS MRI lexicon had a high diagnostic performance for the characterization of US-indeterminate adnexal lesions," the researchers wrote. "Summary estimates of malignancy rates in the categories O-RADS MRI 4 and O-RADS MRI 5 were higher than predicted ones."

Reference:

The study titled "O-RADS MRI: A Systematic Review and Meta-Analysis of Diagnostic Performance and Category-wise Malignancy Rates" was published in the journal Radiology.

DOI: https://doi.org/10.1148/radiol.220795