Perioperative Abdominopelvic CT tied to development of Hematologic Malignant Neoplasms
Whether computed tomographic (CT) radiation really induces cancers remains controversial. However, in children and adolescents, the association between CT radiation and carcinogenesis seems plausible given the supporting results of multiple large epidemiological studies. A recent study suggests perioperative abdominopelvic CT radiation is associated with a higher incidence of hematologic malignant neoplasms. The study findings are published in the JAMA Surgery on January 20, 2021.
Patients with acute appendicitis make up a very relevant target population for the investigation of carcinogenic risk of CT. Appendicitis is the most common benign disease with a reported incidence of 100 to 206 per 100 000 person-years. Even if the carcinogenic risk of CT is very small, the risk in such a large number of exposed patients may lead to a measurable number of excess cancers. Redbone marrow is the most radiosensitive tissues, the carcinogenic risk of hematologic malignant neoplasms from ionizing radiation has been of particular concern. Besides, more than 10% of whole-body red bone marrow is distributed in os coxae, which is covered by abdominopelvic CT. To evaluate this further, researchers conducted a study and measured the risk of hematologic malignant neoplasms after perioperative abdominopelvic CT in patients who underwent appendectomy for appendicitis in South Korea.
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