Rapid onsite FFR-CT algorithm shows excellent performance for diagnosing hemodynamically significant stenosis

Switzerland: A high-speed onsite deep-learning based fractional flow reserve (FFR)-CT algorithm yielded excellent diagnostic performance for hemodynamically significant stenosis, with high interobserver and intraobserver reproducibility, according to an accepted manuscript published in ARRS’ own American Journal of Roentgenology (AJR). 

“A rapid and accurate onsite approach for determining FFR-CT should address challenges encountered in the clinical adoption of prior FFR-CT implementations,” wrote corresponding author Ronny Ralf Buechel, MD, from University Hospital Zurich in Switzerland.

In this AJR accepted manuscript, 59 patients (46 men, 13 women; mean age 66.5 years) underwent coronary CTA (including calcium scoring) followed within 90 days by invasive angiography with invasive FFR and/or instantaneous wave-free ratio (iwFR) measurements from December 2014 to October 2021. Coronary artery lesions were considered to show hemodynamically significant stenosis in the presence of invasive FFR ≤0.80 and/or iwFR ≤0.89. A single cardiologist evaluated CTA images using an onsite deep-learning based semiautomated algorithm employing a 3D computational flow dynamics model to determine FFR-CT for coronary artery lesions detected by invasive angiography. Then, time for FFR-CT analysis was recorded. FFR-CT analysis was repeated by the same cardiologist in 26 randomly selected examinations and by a different cardiologist in 45 randomly selected examinations.