Sirolimus promising therapy for Lymphatic Malformations in kids, find MRI studies
Lymphatic malformations are abnormalities that arise in the developing lymphatic system, most frequently presenting in the head and neck. A recent study published in the American Journal of Roentgenology suggests treatment with sirolimus in lymphatic malformations in children is associated with significant reductions in volume and signal on T2-weighted MRI.
Extensive lymphatic malformations may cause substantial morbidity. They are typically treated with sclerotherapy, laser therapy, or surgery for localized lesions. Sirolimus, an inhibitor of the mammalian target of rapamycin (mTOR), is a relatively new medical therapy for the treatment of vascular malformations. As the response assessment is not standardized, a research team conducted a study to retrospectively characterize changes on MRI in extensive LM in children treated with sirolimus.
It was a retrospective study on Twenty-five children treated with sirolimus for extensive LM. Researchers determined that MRI closest to therapy initiation as baseline MRI and most recent MRI while on therapy as a follow-up MRI.
"Two pediatric radiologists independently determined MRI lesion volume by tracing lesion contours on all slices (normalized to patient body mass index) and signal by placing an ROI on lesions' dominant portion (normalized to CSF signal), on baseline and follow-up T2-weighted sequences," the authors wrote. They determined the Inter-reader agreement and averaged values for further analysis. They compared Volume and signal changes with patient, lesion, and therapy characteristics.
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