Ultrasound-assisted laser technique vaporizes artery plaque

"In conventional laser angioplasty, a high laser power is required for the entire cavitation process, whereas in our technology, a lower laser power is only required for initiating the cavitation process," said Singh. "Overall, the combination of ultrasound and laser reduces the need for laser power and improves the efficiency of atherosclerotic plaque removal."

Because it destroys rather than compresses the plaque, the combination technique will have a lower restenosis rate, or re-narrowing of the artery, compared to balloon angioplasty or stenting. The control provided by the ultrasound and the low-power laser will lower the risk of dissection and perforation in arteries.

The team performed ex vivo experiments on carotid artery plaque samples and pork belly samples, and they are currently planning to perform in vivo experiments. Both the laser and ultrasound techniques are commonly used by clinicians and should be easy to teach and implement following the in vivo studies.

Combining low-power lasers and ultrasound techniques is not limited to atherosclerosis treatments. Singh and collaborators are also using the methodology for photo-mediated ultrasound therapy and ultrasound-assisted endovascular laser thrombolysis. The former can be used to remove abnormal microvessels in the eye to prevent blindness, while the latter can dissolve blood clots in veins.