Soon, eye drops to clear up cataracts
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Washington:Scientists, including one of Indian-origin, have discovered a new chemical that could be added to eye drops to help clear up cataracts, the leading cause of blindness.
Although cataracts can be successfully removed with surgery, this approach is expensive, and most individuals blinded by severe cataracts in developing countries go untreated, researchers said.
Cataracts are primarily a disease of ageing. As is seen in neurodegenerative conditions such as Alzheimer's disease and Parkinson's disease, a hallmark of the condition is the misfolding and clumping together of crucial proteins.
In the case of cataracts, the affected proteins are known as crystallins.
Crystallins are the major component of fibre cells, which form the eyes' lenses, and the unique properties of these cells make them particularly susceptible to damage, said Jason Gestwicki, from University of California, San Francisco (UCSF), co-senior author of the research paper.
In the new study, led by Leah N Makley and Kathryn McMenimen, the team exploited a crucial difference between properly folded crystallins and their amyloid forms: amyloids are harder to melt.
Although cataracts can be successfully removed with surgery, this approach is expensive, and most individuals blinded by severe cataracts in developing countries go untreated, researchers said.
Cataracts are primarily a disease of ageing. As is seen in neurodegenerative conditions such as Alzheimer's disease and Parkinson's disease, a hallmark of the condition is the misfolding and clumping together of crucial proteins.
In the case of cataracts, the affected proteins are known as crystallins.
Crystallins are the major component of fibre cells, which form the eyes' lenses, and the unique properties of these cells make them particularly susceptible to damage, said Jason Gestwicki, from University of California, San Francisco (UCSF), co-senior author of the research paper.
In the new study, led by Leah N Makley and Kathryn McMenimen, the team exploited a crucial difference between properly folded crystallins and their amyloid forms: amyloids are harder to melt.
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