Case report of non-healing diabetic foot ulcers treated with Amniotic membrane
Placental amniotic membranes are composed of cells, extra-cellular matrix (ECM), and a complex of regulatory cytokines which promote cell proliferation, cell modulation, and cytokine secretion by variety of cell types involved in wound healing.
However, diabetic ulcer of the foot is a major cause of morbidity and is a leading cause of hospitalization in patients with diabetes, and causes productivity and financial losses that lower the quality of life of the patient. The wound is categorized as responsive and unresponsive wound, which occurs in debilitated patients as seen in diabetes mellitus. Unresponsive diabetic ulcer is ulcer that does not reduce in size within a month. The delay in wound repair can be caused by senescent cells, absence of growth factors, and other cellular abnormalities.
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