Adalimumab effective in moderate to severe hidradenitis suppurativa: JAMA study
Adalimumab was efficacious in patients with hidradenitis suppurativa (HS), with no need to interrupt treatment prior to surgery, suggests a recent study conducted by a team of researchers from the Department of Dermatology, Venereology, and Allergology, St Josef Hospital, Ruhr-University Bochum, Bochum, Germany.
The study is published in the JAMA Network.
Surgery is a mainstay in the management of hidradenitis suppurativa (HS). Adalimumab is the first drug approved for hidradenitis suppurativa.
Falk G. Bechara and colleagues investigated the efficacy and safety of adalimumab in combination with wide-excision surgery followed by secondary intention healing.
The Safety and Efficacy of Adalimumab for Hidradenitis Suppurativa Peri-Surgically (SHARPS) trial was a phase 4, randomized, double-blind, placebo-controlled study of adalimumab in conjunction with surgery.
Overall, 103 patients were randomized to adalimumab and 103 to matching placebo. Patients were enrolled and those eligible, aged 18-65 years had moderate to severe hidradenitis suppurativa that required radical surgery in an axillary or inguinal region and had 2 other anatomical regions affected, with 1 or more regions at Hurley stage II or III.
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