Aspirin 'at par' with other anticoagulants used for VTE after THR/TKR: JAMA
UK: Aspirin seemed to be equally safe and effective as the standard anticoagulants used for VTE (venous thromboembolism) prophylaxis after total hip replacement (THR) or total knee replacement (TKR) in a recent review.
According to the study, published in the journal JAMA Internal Medicine, compared with the use of anticoagulants -- low-molecular-weight heparin (LMWH) and rivaroxaban (Xarelto) -- aspirin use was not associated with more major bleeding, wound complications, or death. In fact, aspirin was associated with a reduced risk of bruising and lower-limb edema.
Patients undergoing THR and TKR receive VTE pharmacoprophylaxis but it is not clear which anticoagulant is preferable. Observational studies suggest aspirin to provide effective VTE prophylaxis. Gulraj S. Matharu, Musculoskeletal Research Unit, Bristol Medical School, Southmead Hospital, University of Bristol, Bristol, United Kingdom, and colleagues conducted this systematic review and meta-analysis of 13 RCTs to assess the effectiveness and safety of aspirin for VTE prophylaxis after THR and TKR.
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