Breast-conserving surgery appropriate procedure for centrally located breast cancer

Results

With a median follow-up of 91 months, the BCSS and OS rates in patients who received BCT were greater than those patients treated with mastectomy in the entire CLBC set. Multivariable Cox analyses showed that CLBC patients who received BCT had better BCSS (HR = 0.67, 95%CI: 0.55–0.80, p < 0.001) and OS (HR = 0.78, 95%CI: 0.68–0.90, p = 0.001) than patients who received a mastectomy, but there were no significant differences of BCSS (HR = 0.65, 95%CI: 0.47–0.90, p = 0.009) and OS (HR = 0.82, 95%CI: 0.65–1.04, p = 0.110) after PSM. In patients treated with BCT, CLBC patients had a similar BCSS (HR = 0.99, 95%CI: 0.87–1.12, p = 0.850) but a worse OS (HR = 1.09, 95%CI: 1.01–1.18, p = 0.040) compared to that of the non-CLBC patient, but there was no significant difference both BCSS (HR = 1.05, 95%CI: 0.88–1.24, p = 0.614) and OS (HR = 1.08, 95%CI: 0.97–1.20, p = 0.168) after PSM.

The findings revealed that BCT should be an acceptable and preferable alternative to mastectomy for well-selected patients with CLBC.

Reference:

Yuan, YW., Liu, PC., Li, FF. et al. Breast-conserving surgery is an appropriate procedure for centrally located breast cancer: a population-based retrospective cohort study. BMC Surg 23, 298 (2023). https://doi.org/10.1186/s12893-023-02181-6

Keywords:

Breast-conserving, surgery, appropriate, procedure, centrally, located, breast, cancer, BMC Surgery, Yuan, YW., Liu, PC., Li, FF