Chemical sphincterotomy with calcium channel blockers effectively relieves pain after haemorrhoidectomy
Haemorrhoid is one of the most common anal diseases in the world, and it is estimated that the lifetime risk of developing haemorrhoids in the general population may be as high as 75%. Surgical treatment remains the primary modality indicated for high-grade haemorrhoids.
Chemical sphincterotomy with calcium channel blockers effectively relieves pain after haemorrhoidectomy finds a new study.
The study has been published in the BMC Surgery.
This study aims to evaluate the pain relief function of chemical sphincterotomy in patients undergoing haemorrhoid surgery and compare, through a meta-analysis, the different drugs used to treat this condition.
Researchers conducted a search in databases including PubMed, EMBASE and Web of Science. The methodological quality was evaluated using the Revised Cochrane risk-of-bias tool for randomized trials (ROB2). The pain score was assessed using a visual analogue scale (VAS) on day 1, day 2, and day 7, and a meta-analysis was conducted based on the use of random effects models. In addition, the subgroup analysis was evaluated based on the kind of experimental drugs. Heterogeneity and publication bias were assessed.
Results
Fourteen studies with a total of 681 patients were included in this meta-analysis, and all studies were randomized controlled trials RCTs. Chemical sphincterotomy showed better pain relief function than placebo on day 1 (SMD: 1.16, 95% CI 0.52 to 1.80), day 2 (SMD: 2.12, 95% CI 1.37 to 2.87) and day 7 (SMD: 1.97, 95% CI 1.17 to 2.77) after surgery. In the subgroup meta-analysis, we found that different drugs for chemical sphincterotomy provided different pain relief.
Chemical sphincterotomy effectively relieves pain after haemorrhoidectomy, and calcium channel blockers have the best effect.
Reference:
Cheng, Y., Mao, M., Shang, Y. et al. Chemical sphincterotomy in posthemorrhoidectomy pain relief: a meta-analysis. BMC Surg 23, 113 (2023). https://doi.org/10.1186/s12893-023-02025-3
Keywords:
Chemical, sphincterotomy, calcium, channel, blockers, effectively, relieves, pain, haemorrhoidectomy, BMC Surgery, Cheng, Y., Mao, M., Shang, Y.
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