Cholecystectomy in Type 2 Diabetes Patients Linked to Increased Mortality: Study
Researchers have found in a new study that patients with type 2 diabetes (T2D) who are subjected to cholecystectomy could be at an increased risk of death, especially young patients and those not on diabetes medication. The study was conducted by Han N. J. and fellow researchers published in the Journal of Hepato-Biliary-Pancreatic Sciences.
Cholecystectomy, a routine surgery for gallbladder disease, has established short-term advantages. Its long-term influence on death and cardiovascular disease, particularly among patients with diabetes, is less well understood. Considering the metabolic and inflammatory remodeling that occurs in response to removal of the gallbladder, investigators sought to establish its effect on long-term health outcomes among patients with T2D.
2,216,930 patients with T2D who underwent a national health examination were included in this study. Among them, 19,258 patients had undergone cholecystectomy. Participants were followed up for a median of 7.9 years. Researchers estimated adjusted hazard ratios (aHRs) to contrast all-cause mortality and CVD risk (myocardial infarction or ischemic stroke) in patients who had undergone cholecystectomy versus those who had not.
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